Epidermal growth factor receptor: mechanisms of activation and signalling

Exp Cell Res. 2003 Mar 10;284(1):31-53. doi: 10.1016/s0014-4827(02)00098-8.


The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-alpha, and the neuregulins. We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell. The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Movement
  • ErbB Receptors / metabolism*
  • Humans
  • Models, Molecular
  • Protein Conformation
  • Signal Transduction*
  • Transforming Growth Factors / metabolism


  • Transforming Growth Factors
  • ErbB Receptors