Ras pathway signaling on endomembranes

Curr Opin Cell Biol. 2003 Apr;15(2):136-42. doi: 10.1016/s0955-0674(03)00016-4.


Until recently, the plasma membrane has been considered to be a unique platform from which emanate the signaling events regulating or regulated by Ras and its close relatives. For the past few years, the role of endosomes derived from the plasma membrane as platforms for Ras/mitogen-activated protein kinase signaling has been appreciated. More recently, the cytoplasmic face of the Golgi apparatus and endoplasmic reticulum have been shown to host Ras signaling. The biological implications of compartmentalized signaling are only beginning to emerge.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Compartmentation / physiology*
  • Endoplasmic Reticulum / physiology
  • Endosomes / metabolism*
  • Eukaryotic Cells / metabolism*
  • Golgi Apparatus / physiology
  • Humans
  • Intracellular Membranes / metabolism*
  • MAP Kinase Signaling System / physiology*
  • ras Proteins / metabolism*


  • ras Proteins