Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell

Curr Opin Cell Biol. 2003 Apr;15(2):221-31. doi: 10.1016/s0955-0674(03)00017-6.


The physiological responses of cells to external and internal stimuli are governed by genes and proteins interacting in complex networks whose dynamical properties are impossible to understand by intuitive reasoning alone. Recent advances by theoretical biologists have demonstrated that molecular regulatory networks can be accurately modeled in mathematical terms. These models shed light on the design principles of biological control systems and make predictions that have been verified experimentally.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Clocks / physiology
  • Eukaryotic Cells / metabolism*
  • Feedback, Physiological / physiology
  • Genomics / methods*
  • Genomics / trends
  • Humans
  • Models, Biological*
  • Proteomics / methods*
  • Proteomics / trends
  • Signal Transduction / physiology*