Collapsin response mediator protein-1: a novel invasion-suppressor gene

Clin Exp Metastasis. 2003;20(1):69-76. doi: 10.1023/a:1022598604565.


Numerous genetic changes are associated with metastasis of cancer cells. Previously, we used microarray to identify that collapsin response mediator protein-1 (CRMP-1) was involved in cancer invasion and metastasis. We further characterized that CRMP-1 was a novel invasion-suppression gene. Members of the CRMP gene family are intracellular phosphoproteins involved in the mediation of semaphorin induced F-actin depolymerization and growth cone collapse. The precise mechanism by which CRMP-I inhibits invasion is not yet clear. However, CRMP-1 transfected cells had fewer filopodia and less Matrigel-invasion abilities. A low expression of CRMP-I mRNA in lung cancer tissue was significantly associated with advanced disease, lymph node metastasis, early post-operative relapse, and shorter survival. In this article, we reviewed the functions of CRMPs and semaphorins and analyzed the structure and motifs of CRMP-1 by bioinformatics. As such, we hoped to shed further light on the mechanism by which CRMP-1 suppresses the invasion of cancer cells.

Publication types

  • Review

MeSH terms

  • Endothelial Growth Factors / metabolism
  • Genes, Tumor Suppressor*
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Lymphokines / metabolism
  • Mitosis
  • Neoplasm Metastasis / genetics*
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / genetics*
  • Nuclear Localization Signals
  • Phosphoproteins / chemistry
  • Phosphoproteins / genetics*
  • Protein Biosynthesis
  • Protein Processing, Post-Translational
  • Semaphorin-3A / metabolism
  • Semaphorins / physiology
  • Signal Transduction
  • T-Box Domain Proteins / metabolism
  • Transcription, Genetic
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors


  • Endothelial Growth Factors
  • Intercellular Signaling Peptides and Proteins
  • Lymphokines
  • Nerve Tissue Proteins
  • Nuclear Localization Signals
  • Phosphoproteins
  • Semaphorin-3A
  • Semaphorins
  • T-Box Domain Proteins
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
  • collapsin response mediator protein-1