Innate and adaptive immune responses to an intracellular bacterium, Francisella tularensis live vaccine strain

Microbes Infect. 2003 Feb;5(2):135-42. doi: 10.1016/s1286-4579(02)00084-9.


The immune response to intracellular bacterium, Francisella tularensis, which causes tularemia and is proposed to be a potential bioterrorism pathogen, has been studied in mice using the attenuated live vaccine strain (LVS). Here we review this infection model, which provides a convenient means of studying protective immune mechanisms not only for Francisella, but also for the large and important class of intracellular pathogens.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Bacterial / blood*
  • Bacterial Vaccines / administration & dosage
  • Bacterial Vaccines / immunology*
  • Disease Models, Animal
  • Francisella tularensis / immunology*
  • Immunity, Cellular*
  • Immunity, Innate*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C3H
  • Mice, Knockout
  • Tularemia / immunology
  • Tularemia / prevention & control
  • Vaccination
  • Vaccines, Attenuated / administration & dosage
  • Vaccines, Attenuated / immunology*


  • Antibodies, Bacterial
  • Bacterial Vaccines
  • Vaccines, Attenuated