Innate and adaptive immune responses to an intracellular bacterium, Francisella tularensis live vaccine strain

Karen L Elkins; Siobhán C Cowley; Catharine M Bosio

doi:10.1016/s1286-4579(02)00084-9

Innate and adaptive immune responses to an intracellular bacterium, Francisella tularensis live vaccine strain

Microbes Infect. 2003 Feb;5(2):135-42. doi: 10.1016/s1286-4579(02)00084-9.

Authors

Karen L Elkins¹, Siobhán C Cowley, Catharine M Bosio

Affiliation

¹ Laboratory of Mycobacteria, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA. elkins@cber.fda.gov

PMID: 12650771
DOI: 10.1016/s1286-4579(02)00084-9

Abstract

The immune response to intracellular bacterium, Francisella tularensis, which causes tularemia and is proposed to be a potential bioterrorism pathogen, has been studied in mice using the attenuated live vaccine strain (LVS). Here we review this infection model, which provides a convenient means of studying protective immune mechanisms not only for Francisella, but also for the large and important class of intracellular pathogens.

Publication types

Review

MeSH terms

Animals
Antibodies, Bacterial / blood*
Bacterial Vaccines / administration & dosage
Bacterial Vaccines / immunology*
Disease Models, Animal
Francisella tularensis / immunology*
Immunity, Cellular*
Immunity, Innate*
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Knockout
Tularemia / immunology
Tularemia / prevention & control
Vaccination
Vaccines, Attenuated / administration & dosage
Vaccines, Attenuated / immunology*

Substances

Antibodies, Bacterial
Bacterial Vaccines
Vaccines, Attenuated