Minimally invasive surgical management of primary venous ulcers vs. compression treatment: a randomized clinical trial

Eur J Vasc Endovasc Surg. 2003 Apr;25(4):313-8. doi: 10.1053/ejvs.2002.1871.


Objectives: to compare minimally invasive surgical haemodynamic correction of reflux (CHIVA) with compression in the treatment of venous ulceration.

Design: prospective randomised study.

Materials and methods: from a cohort of 80 patients with 87 venous leg ulcers, 47 were randomised to either surgery or compression.

Results: at a mean follow-up of 3 years, healing was 100% (31 days) in the surgical and 96% (63 days), in the compression group (p<0.02). The recurrence rate was 9% in the surgical and 38% in the compression group (p<0.05). In the surgical group, all plethysmographic parameters except ejection fraction, had improved significantly at 6 months in the surgical group, and at 3 years residual volume fraction remained in the normal range. Finally, quality of life significantly improved in the operated group.

Conclusions: this study supports the effectiveness of surgical therapy for leg ulceration secondary to superficial venous reflux.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Bandages*
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • Hemodynamics / physiology
  • Humans
  • Male
  • Middle Aged
  • Minimally Invasive Surgical Procedures*
  • Outcome Assessment, Health Care
  • Prospective Studies
  • Time Factors
  • Varicose Ulcer / physiopathology
  • Varicose Ulcer / surgery*
  • Varicose Ulcer / therapy*