Interleukin-17 family and IL-17 receptors

Cytokine Growth Factor Rev. 2003 Apr;14(2):155-74. doi: 10.1016/s1359-6101(03)00002-9.


Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated T-cells. Recently discovered related molecules are forming a family of cytokines, the IL-17 family. The prototype member of the family has been designated IL-17A. Due to recent advances in the human genome sequencing and proteomics five additional members have been identified and cloned: IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. The cognate receptors for the IL-17 family identified thus far are: IL-17R, IL-17RH1, IL-17RL (receptor like), IL-17RD and IL-17RE. However, the ligand specificities of many of these receptors have not been established. The IL-17 signaling system is operative in disparate tissues such as articular cartilage, bone, meniscus, brain, hematopoietic tissue, kidney, lung, skin and intestine. Thus, the evolving IL-17 family of ligands and receptors may play an important role in the homeostasis of tissues in health and disease beyond the immune system. This survey reviews the biological actions of IL-17 signaling in cancers, musculoskeletal tissues, the immune system and other tissues.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Arthritis / metabolism
  • Cartilage / metabolism
  • Cartilage, Articular / metabolism
  • Disease Models, Animal
  • Interleukin-17 / physiology*
  • Ligands
  • Microscopy, Fluorescence
  • Models, Biological
  • Models, Genetic
  • Molecular Sequence Data
  • Neoplasms / metabolism
  • Phylogeny
  • Receptors, Interleukin / physiology*
  • Recombinant Proteins
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • T-Lymphocytes / metabolism
  • Tissue Distribution


  • Interleukin-17
  • Ligands
  • Receptors, Interleukin
  • Recombinant Proteins