Abstract
The issue of whether pain is represented by specific neural elements or by patterned activity within a convergent somatosensory subsystem has been debated for over a century. The gate control theory introduced in 1965 denied central specificity, and since then most authors have endorsed convergent wide-dynamic-range neurons. Recent functional and anatomical findings provide compelling support for a new perspective that views pain in humans as a homeostatic emotion that integrates both specific labeled lines and convergent somatic activity.
Publication types
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Historical Article
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Afferent Pathways / anatomy & histology
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Afferent Pathways / physiology
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Animals
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History, 19th Century
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History, 20th Century
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Humans
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Models, Neurological
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Neurons / classification
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Neurons / physiology
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Pain / classification
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Pain / history
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Pain / physiopathology*
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Peripheral Nerves / anatomy & histology
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Peripheral Nerves / physiology
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Somatosensory Cortex / anatomy & histology
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Somatosensory Cortex / physiology
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Spine / cytology
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Spine / physiology
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Thalamus / anatomy & histology
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Thalamus / physiology