Nitric oxide and cardiovascular protection

Heart Fail Rev. 2003 Jan;8(1):29-34. doi: 10.1023/a:1022190820131.

Abstract

Nitric oxide (NO) plays a critical role in ischemic heart disease and ischemia-reperfusion. There is an increasing body of evidence to support the role of NO in myocardial and vascular protection in disease. The finding that NO might act as a trigger of late ischemic preconditioning (IPC) might lead to the development of novel anti-ischemic therapy. The role of NO signaling in the cardioprotective effects of ACE inhibitors and angiotensin II type 1 receptor(AT(1)) receptor antagonists is an active area of study.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiotensin Receptor Antagonists
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Cardiotonic Agents / therapeutic use*
  • Cardiovascular Diseases / physiopathology*
  • Cardiovascular Diseases / prevention & control*
  • Evidence-Based Medicine
  • Humans
  • Ischemic Preconditioning, Myocardial
  • Nitric Oxide / physiology*
  • Nitric Oxide / therapeutic use*
  • Receptor, Angiotensin, Type 1
  • Receptors, Angiotensin / therapeutic use

Substances

  • Angiotensin Receptor Antagonists
  • Angiotensin-Converting Enzyme Inhibitors
  • Cardiotonic Agents
  • Receptor, Angiotensin, Type 1
  • Receptors, Angiotensin
  • Nitric Oxide