Proton beam therapy in the management of central nervous system tumors in childhood: the preliminary experience of the Centre de Protonthérapie d'Orsay

Med Pediatr Oncol. 2003 May;40(5):309-15. doi: 10.1002/mpo.10283.

Abstract

Background: The purpose of the study was to evaluate clinical results and complications of a combination of proton and photon irradiation administered to 17 children with selected central nervous system (CNS) tumors.

Procedure: Between July 1994 and September 2000, 17 children, aged from 5 to 17 years (median: 12 years) with intracranial benign (6 cases) or malignant (11 cases) tumors, were treated with photons (median dose: 40 Gy; 24-54) and protons (median dose: 20 CGE; 9-31) at the Centre de Protonthérapie d'Orsay (CPO).

Results: Mean follow-up was 27 months (3-81). Two patients recurred locally (one marginal and one in situ). Fifteen patients are alive and doing well. Overall, 12, 24, and 36-month local control rate was 92 +/- 8% and, 12, 24, and 36-month overall survival rates were 93 +/- 6%, 83 +/- 11%, and 83 +/- 11%, respectively. Clinical initial symptoms remained stable or subsided in all patients. Early toxicities were in the expected range.

Conclusions: With a mean 27 months follow-up, protontherapy was well tolerated for doses upto 69 CGE and with an excellent local control rate.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Adolescent
  • Central Nervous System Neoplasms / mortality
  • Central Nervous System Neoplasms / pathology
  • Central Nervous System Neoplasms / radiotherapy*
  • Child
  • Cranial Irradiation / adverse effects
  • Cranial Irradiation / methods*
  • Disease-Free Survival
  • Female
  • France / epidemiology
  • Humans
  • Male
  • Protons*
  • Radiotherapy Dosage
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy, Conformal / adverse effects
  • Radiotherapy, Conformal / methods*
  • Survival Rate

Substances

  • Protons