Complete cDNA coding sequence of the HLA-DRB1*1405 allele

Hitoshi Kohsaka; Kimio Nasu; Sho Matsushita; Nobuyuki Miyasaka

doi:10.1080/1042517021000041822

Complete cDNA coding sequence of the HLA-DRB1*1405 allele

DNA Seq. 2002 Dec;13(6):359-61. doi: 10.1080/1042517021000041822.

Authors

Hitoshi Kohsaka¹, Kimio Nasu, Sho Matsushita, Nobuyuki Miyasaka

Affiliation

¹ Department of Bioregulatory Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. kohsaka.rheu@tmd.ac.jp

PMID: 12652907
DOI: 10.1080/1042517021000041822

Abstract

Cloning report of complete coding region of HLA-DRB1*1405 has never appeared in the literature. We have isolated and sequenced it from a B cell line with a DRB1*1405/1502 genotype. The sequence information of this gene and previously published DRB1 genes for the other DR serotypes facilitated us to find that the cytoplasmic domain sequences of DRB1 genes fall into three groups. It is known that antigen presenting cells are differentially activated when products of different MHC class II genes are triggered. Functional analyses would discern if these allelic differences in the cytoplasmic domain are of functional significance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Base Sequence
DNA, Complementary*
HLA-DR Antigens / genetics*
HLA-DRB1 Chains
Humans
Molecular Sequence Data

Substances

DNA, Complementary
HLA-DR Antigens
HLA-DRB1 Chains

Associated data

GENBANK/AB062112