Abnormal endothelial function in young African-American females: discordance with blood flow

J Natl Med Assoc. 2001 Apr;93(4):113-9.


In this pilot study, we sought to compare the vasodilatory and hemodynamic properties of the peripheral vasculature in the forearms of young, healthy African-American females to similarly matched white females. We used high-resolution ultrasound of the brachial artery to evaluate 11 African-American females and 8 white females. When normalized to nitrate-induced dilation, endothelium-dependent dilation was reduced in young African American females compared to white females (0.6 in African American females compared to 1.0 in white females). These results indicate the need for a larger study to examine this phenomenon.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Black or African American*
  • Blood Flow Velocity
  • Brachial Artery / diagnostic imaging*
  • Brachial Artery / physiology
  • Endothelium, Vascular / drug effects*
  • Endothelium, Vascular / physiopathology*
  • Female
  • Humans
  • Nitroglycerin / pharmacology*
  • Pilot Projects
  • Probability
  • Prospective Studies
  • Reference Values
  • Sampling Studies
  • Sensitivity and Specificity
  • Ultrasonography
  • Upper Extremity
  • Vasoconstriction / drug effects
  • Vasodilation / drug effects
  • Vasomotor System / physiology
  • White People*


  • Nitroglycerin