Translational regulation of the plant S-adenosylmethionine decarboxylase

Biochem Soc Trans. 2003 Apr;31(2):424-7. doi: 10.1042/bst0310424.


It is becoming apparent that control of protein synthesis by metabolites is more common than previously thought. Much of that control is exerted at the level of initiation of mRNA translation, orchestrated by upstream open reading frames (uORFs) and RNA secondary structure. S-Adenosylmethionine decarboxylase (AdoMetDC) is a key enzyme in polyamine biosynthesis and both mammalian and plant AdoMetDCs are translationally regulated by uORFs in response to polyamine levels by distinct mechanisms.

Publication types

  • Review

MeSH terms

  • Adenosylmethionine Decarboxylase / biosynthesis*
  • Animals
  • Biogenic Polyamines / biosynthesis
  • Gene Expression Regulation
  • Humans
  • Open Reading Frames / physiology
  • Plants / enzymology*
  • Protein Biosynthesis*


  • Biogenic Polyamines
  • Adenosylmethionine Decarboxylase