Detection of HHV-8 sequences and antigens in a MALT lymphoma associated with Sjögren's syndrome

J Oral Pathol Med. 2003 Apr;32(4):243-5. doi: 10.1034/j.1600-0714.2003.00092.x.


We describe the case of a bilateral parotid mucosa-associated lymphoid tissue (MALT) lymphoma associated with 2 years history of Sjögren's syndrome (SS), which was linked to human herpes virus 8 (HHV-8) infection. Using polymerase chain reaction (PCR) assay HHV-8 sequences were detectable in the lymphoma tissue of both sides. Serologic testing of the patient revealed HHV-8 antibodies in enzyme-linked immunosorbent assay (ELISA) and immunofluorescence assay (IFA). Immunohistologic staining with two antibodies against open reading frame (ORF) 26 and v-cyclin homologues of HHV-8 revealed positive staining of the salivary acinic cells whereas the lymphoma cells were negative. The potential influence of HHV-8 infection for MALT lymphoma development in this case and possible parallels to gastric MALT lymphoma are discussed.

Publication types

  • Case Reports

MeSH terms

  • Antigens, Viral / analysis*
  • Cyclins / analysis
  • DNA, Viral / analysis*
  • Epithelium / virology
  • Female
  • Follow-Up Studies
  • Herpesvirus 8, Human / genetics
  • Herpesvirus 8, Human / immunology
  • Herpesvirus 8, Human / isolation & purification*
  • Humans
  • Lymphoma, B-Cell, Marginal Zone / virology*
  • Middle Aged
  • Open Reading Frames / genetics
  • Parotid Gland / virology
  • Parotid Neoplasms / virology*
  • Sjogren's Syndrome / complications*
  • Viral Proteins


  • Antigens, Viral
  • Cyclins
  • DNA, Viral
  • Viral Proteins