Membranes, trafficking, and signaling during animal development

Cell. 2003 Mar 21;112(6):745-9. doi: 10.1016/s0092-8674(03)00198-3.


Molecular genetics has been key in allowing developmental biologists to uncover many of the molecules that participate in pattern formation. Cell biology is now beginning to help developmental biologists in their quest to understand how these molecules interact within cells to direct tissue behavior. This is particularly true in the areas of membrane trafficking and cell motility. Recent work has shown that various trafficking events such as secretion, endocytosis, segregation in membrane microdomains, intracellular transport, and targeting to lysosomes regulate various signaling pathways. It is likely that within the context of an embryo, these trafficking events are integrated such that secreted factors reliably orchestrate many developmental decisions.

Publication types

  • Congress
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Transport, Active
  • Cell Compartmentation
  • Cell Membrane / physiology*
  • Cell Movement
  • Cytoskeleton / metabolism
  • Embryonic Development*
  • Endocytosis / physiology
  • Forecasting
  • Lipid Metabolism
  • Membrane Microdomains / physiology
  • Models, Biological
  • Protein Transport / physiology*
  • Signal Transduction*