Insights on antibiotic resistance of Staphylococcus aureus from its whole genome: genomic island SCC

Drug Resist Updat. 2003 Feb;6(1):41-52. doi: 10.1016/s1368-7646(03)00003-7.


Staphylococci are ubiquitous colonizers of the skin and mucous membranes and Staphylococcus aureus is the most pathogenic species. The spread of antibiotic resistance among S. aureus strains is a major concern in the treatment of staphylococcal infections. Acquisition of resistance may involve mutation of a bacterial gene on the chromosome or transfer of a resistance gene from other organisms by some form of genetic exchange (conjugation, transduction, or transformation). Completion of whole genome sequences of three methicillin-resistant S. aureus (MRSA) strains has provided us a bird's-eye view of the distribution of the mobile genetic elements in the bacterial chromosome that encode antibiotic resistance as well as pathogenicity in S. aureus.

Publication types

  • Review

MeSH terms

  • Community-Acquired Infections / drug therapy
  • Community-Acquired Infections / microbiology
  • Cross Infection / drug therapy
  • Cross Infection / microbiology
  • DNA Transposable Elements
  • Drug Resistance, Bacterial / genetics*
  • Drug Resistance, Multiple, Bacterial / genetics
  • Genome, Bacterial*
  • Methicillin Resistance / genetics
  • Mutation
  • Staphylococcal Infections / drug therapy
  • Staphylococcal Infections / microbiology
  • Staphylococcus aureus / drug effects
  • Staphylococcus aureus / genetics*


  • DNA Transposable Elements