In vitro metronidazole and tinidazole activities against metronidazole-resistant strains of Trichomonas vaginalis

Antimicrob Agents Chemother. 2003 Apr;47(4):1407-9. doi: 10.1128/AAC.47.4.1407-1409.2003.


The in vitro activities of tinidazole and metronidazole against Trichomonas vaginalis isolates clinically resistant to metronidazole were compared. Minimal lethal concentrations (MLCs) of tinidazole were significantly lower than MLCs of metronidazole. Increased metronidazole resistance correlated with increased tinidazole resistance. These data support a role for tinidazole in the treatment of trichomoniasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Drug Resistance
  • Female
  • Humans
  • Metronidazole / pharmacology*
  • Tinidazole / pharmacology*
  • Trichomonas Vaginitis / drug therapy
  • Trichomonas vaginalis / drug effects*


  • Tinidazole
  • Metronidazole