An integron cassette encoding erythromycin esterase, ere(A), from Providencia stuartii

J Antimicrob Chemother. 2003 Apr;51(4):787-90. doi: 10.1093/jac/dkg169. Epub 2003 Mar 13.

Abstract

We have mapped the variable region of the two class 1 integrons found in the multiresistant strain Providencia stuartii 1723. Integron 1 contains a new arrangement of gene cassettes, aacA4-aadB-aadA1, conferring resistance to all aminoglycosides used for clinical treatment. Integron 2 contains a variant of the gene cassette ere(A), coding for an erythromycin esterase, whose nucleotide sequence shares 93.7% DNA identity with ere(A) from Escherichia coli BM2195 plasmid pIP1100.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carboxylic Ester Hydrolases / genetics*
  • Chromosome Mapping
  • DNA, Bacterial / genetics
  • Drug Resistance, Bacterial
  • Enterobacteriaceae Infections / microbiology
  • Humans
  • Integrons / genetics*
  • Molecular Sequence Data
  • Providencia / enzymology*
  • Providencia / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction

Substances

  • DNA, Bacterial
  • Carboxylic Ester Hydrolases
  • erythromycin esterase

Associated data

  • GENBANK/AF099140