The CD95(APO-1/Fas) DISC and beyond

Cell Death Differ. 2003 Jan;10(1):26-35. doi: 10.1038/sj.cdd.4401186.

Abstract

CD95 (APO-1/Fas) is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. The complex of proteins that forms upon triggering of CD95 is called the death-inducting signaling complex (DISC). The DISC consists of an adaptor protein and initiator caspases and is essential for induction of apoptosis. A number of proteins have been reported to regulate formation or activity of the DISC. This review discusses recent developments in this area of death receptor research.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Caspases / metabolism
  • Death Domain Receptor Signaling Adaptor Proteins
  • Eukaryotic Cells / metabolism*
  • Humans
  • Macromolecular Substances
  • Receptors, Tumor Necrosis Factor / metabolism*
  • Signal Transduction / physiology*
  • fas Receptor / metabolism*

Substances

  • Death Domain Receptor Signaling Adaptor Proteins
  • Macromolecular Substances
  • Receptors, Tumor Necrosis Factor
  • fas Receptor
  • Caspases