Granule cells of the dentate gyrus with basal and recurrent dendrites in schizophrenic patients and controls. A comparative Golgi study

J Neural Transm (Vienna). 2003 Mar;110(3):317-26. doi: 10.1007/s00702-002-0776-6.


We report on structural variability of granule cells in the human dentate gyrus. Granule cells with basal and recurrent dendrites are a normal finding in the human brain. We detect 28.3% granule cells with basal dendrites in non-psychiatrically ill humans compared to rats (2%) and primates (10%). This can be seen as an indication for the higher phylogeny of the human brain. In addition we find a significantly higher incidence of granule cells with basal dendrites (45.7%) in brains of schizophrenic patients. Whereas drug influences during lifetime cannot fully be excluded, we tend to interpret this finding as a plastic reaction to prenatal developmental malformations of the impinging rostral entorhinal region.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cell Differentiation
  • Dendrites / pathology*
  • Dentate Gyrus / cytology
  • Dentate Gyrus / pathology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Schizophrenia / pathology*
  • Silver Staining / methods*