Abstract
[reaction: see text] The conjugate addition of dithiols to bis-ynones generates a versatile masked 1,3,5-triketone platform. These functional units are useful intermediates for the synthesis of oxygen-containing heterocycles commonly found in polyketide natural products. The tetrahydropyranyl fragments of the marine macrolides Lyngbouilloside and Callipeltoside A have been synthesized with use of this methodology.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Biological Products / chemical synthesis*
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Biological Products / chemistry
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Glycosides / chemical synthesis
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Glycosides / chemistry
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Ketones / chemical synthesis*
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Ketones / chemistry
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Macrolides / chemical synthesis
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Macrolides / chemistry
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Molecular Structure
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Sulfhydryl Compounds / chemistry*
Substances
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Anti-Bacterial Agents
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Biological Products
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Glycosides
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Ketones
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Macrolides
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Sulfhydryl Compounds
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callipeltoside A
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lyngbouilloside