Towards Proteome Database of Francisella Tularensis

J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Apr 5;787(1):149-77. doi: 10.1016/s1570-0232(02)00730-4.

Abstract

The accessibility of the partial genome sequence of Francisella tularensis strain Schu 4 was the starting point for a comprehensive proteome analysis of the intracellular pathogen F. tularensis. The main goal of this study is identification of protein candidates of value for the development of diagnostics, therapeutics and vaccines. In this review, the current status of 2-DE F. tularensis database building, approaches used for identification of biologically important subsets of F. tularensis proteins, and functional and topological assignments of identified proteins using various prediction programs and database homology searches are presented.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacterial Proteins / chemistry*
  • Bacterial Proteins / genetics
  • Databases, Protein*
  • Francisella tularensis / chemistry*
  • Proteome*

Substances

  • Bacterial Proteins
  • Proteome