Sarcoglycans of the zebrafish: orthology and localization to the sarcolemma and myosepta of muscle

Biochem Biophys Res Commun. 2003 Apr 4;303(2):488-95. doi: 10.1016/s0006-291x(03)00355-3.


The zebrafish is an established model of vertebrate development and is also receiving increasing attention in terms of human disease modelling. In order to provide experimental support to realize this modelling potential, we report here the identification of apparent orthologues of many critical members of the dystrophin-associated glycoprotein complex (DGC) that have been implicated in a diverse range of neuromuscular disorders. In addition, immunohistochemical studies show the localization of the DGC to the sarcolemma of adult zebrafish muscle and in particular the myosepta. Together, these data suggest that the DGC in adult zebrafish may play a highly conserved functional role in muscle architecture that, when disrupted, could offer insight into human neuromuscular disease processes.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cytoskeletal Proteins / analysis
  • Cytoskeletal Proteins / chemistry
  • Cytoskeletal Proteins / metabolism*
  • Dystroglycans
  • Humans
  • Immunohistochemistry
  • Membrane Glycoproteins / analysis
  • Membrane Glycoproteins / chemistry
  • Membrane Glycoproteins / metabolism*
  • Molecular Sequence Data
  • Muscle Proteins / analysis
  • Muscle Proteins / chemistry
  • Muscle Proteins / metabolism*
  • Muscle, Skeletal / metabolism*
  • Muscle, Skeletal / ultrastructure
  • Phylogeny
  • Sarcolemma / metabolism
  • Sarcolemma / ultrastructure*
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Zebrafish


  • Cytoskeletal Proteins
  • DAG1 protein, human
  • Membrane Glycoproteins
  • Muscle Proteins
  • Dystroglycans