Association of histologic chorioamnionitis, increased levels of cord blood cytokines, and intracerebral hemorrhage in preterm neonates

Biol Neonate. 2003;83(3):166-70. doi: 10.1159/000068924.


The objective of this study was to investigate in a prospective study whether histological chorioamnionitis (ChA) is a risk factor predisposing for intracerebral hemorrhage (ICH), and whether ICH is associated with a systemic fetal inflammation in preterm neonates with a gestational age <32 weeks. 106 neonates were studied; 20 (18.9%) suffered from ICH. ChA occurred significantly more often in neonates with ICH compared to neonates without ICH (70.0 vs. 36.0%, p = 0.006). Neonates with ICH had significantly higher median levels of proinflammatory cytokines (IL-1beta, IL-6 and IL-8) compared to neonates without ICH (p < 0.001 for all comparisons). We conclude that the development of ICH in preterm infants is associated with both ChA and high levels of proinflammatory cytokines at birth.

MeSH terms

  • Cerebral Hemorrhage / complications*
  • Chorioamnionitis / complications*
  • Chorioamnionitis / epidemiology
  • Chorioamnionitis / pathology
  • Cytokines / blood*
  • Female
  • Fetal Blood*
  • Humans
  • Incidence
  • Infant, Newborn
  • Infant, Premature*
  • Inflammation Mediators / blood*
  • Pregnancy


  • Cytokines
  • Inflammation Mediators