Impairment of learning and memory after photothrombosis of the prefrontal cortex in rat brain: effects of Noopept

Bull Exp Biol Med. 2002 Dec;134(6):528-30. doi: 10.1023/a:1022940507519.


Experiments were performed on rats trained conditioned passive avoidance response. Acquisition and retention of memory traces were impaired after photothrombosis of the prefrontal cortex. The acyl-prolyl-containing dipeptide Noopept facilitated retention and retrieval of a conditioned passive avoidance response, normalized learning capacity in animals with ischemic damage to the cerebral cortex, and promoted finish training in rats with hereditary learning deficit. These results show that Noopept improves all three stages of memory. It should be emphasized that the effect of Noopept was most pronounced in animals with impaired mnesic function.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Avoidance Learning / drug effects
  • Brain Injuries / etiology
  • Dipeptides / therapeutic use*
  • Intracranial Thrombosis / complications*
  • Learning / physiology*
  • Light
  • Male
  • Memory Disorders / drug therapy*
  • Memory Disorders / etiology
  • Nootropic Agents / therapeutic use*
  • Prefrontal Cortex / physiopathology*
  • Rats
  • Reaction Time
  • Retention, Psychology / drug effects


  • Dipeptides
  • Nootropic Agents
  • ethyl phenylacetyl-Pro-Gly