Relationship between IL-6, leptin and adiponectin and variables of fibrinolysis in overweight and obese hypertensive patients

Horm Metab Res. Nov-Dec 2002;34(11-12):659-63. doi: 10.1055/s-2002-38253.

Abstract

Impaired fibrinolysis is a common finding in obese humans. This condition is now considered as an established risk factor for thromboembolic complications. Furthermore, obesity is characterized by a specific pattern of circulating concentrations of fat-cell products interleukin-6 (IL-6), leptin, and adiponectin. The aim of our study was to investigate the relationship between these proteins and selected variables of the fibrinolytic system in 74 mildly hypertensive, overweight subjects. Circulating IL-6 and leptin levels showed a positive association with BMI (r = 0.24, p = 0.04 and r = 0.70, p < 0.0001), whereas adiponectin was not correlated to BMI. Interestingly, IL-6 was also positively associated with t-PA/PAI-1 complexes after adjustment for BMI and other anthropometric variables. Leptin was positively correlated with PAI-1 activity and antigen (r = 0.32, p = 0.006 and r = 0.37, p < 0.001, respectively) and negatively with t-PA activity (r = -0.27, p = 0.03). However, these associations lost significance after correction for BMI or HOMA, an insulin sensitivity index. In contrast, adiponectin levels were independently and negatively correlated with PAI-1 antigen (r = -0.26, p = 0.04, after correction for BMI). In conclusion, our study provides further evidence that IL-6, leptin, and adiponectin are associated with impaired fibrinolysis in overweight hypertensive humans.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipocytes / metabolism
  • Adiponectin
  • Adult
  • Aged
  • Body Mass Index
  • Cross-Sectional Studies
  • Fibrinolysis / physiology*
  • Humans
  • Hypertension / blood*
  • Intercellular Signaling Peptides and Proteins*
  • Interleukin-6 / blood*
  • Leptin / blood*
  • Middle Aged
  • Obesity / blood*
  • Proteins / physiology*
  • Statistics as Topic

Substances

  • Adiponectin
  • Intercellular Signaling Peptides and Proteins
  • Interleukin-6
  • Leptin
  • Proteins