Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003;64 Suppl 3:21-7.

The Role of GABA in Anxiety Disorders

  • PMID: 12662130
Free article

The Role of GABA in Anxiety Disorders

R Bruce Lydiard. J Clin Psychiatry. .
Free article


Anxiety stems from and perpetuates dysregulation of neurobiological systems, but the exact mechanisms of anxiety disorders are still only partially understood. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter known to counterbalance the action of the excitatory neurotransmitter glutamate. Several pharmacologic agents target the GABA system and modulate the overall effect of GABA. This article highlights multiple neurobiological interactions that play a role in anxiety and reviews selected studies of plasma neurosteroid levels, plasma GABA levels, and benzodiazepine binding site sensitivity and density in patients with anxiety disorders. The article concludes with further support for the role of the GABA system in anxiety by summarizing the current evidence supporting the use of novel GABAergic agents including tiagabine in the treatment of anxiety disorders.

Similar articles

See all similar articles

Cited by 68 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources