Anterior cingulotomy for refractory obsessive-compulsive disorder

Acta Psychiatr Scand. 2003 Apr;107(4):283-90. doi: 10.1034/j.1600-0447.2003.00087.x.


Objective: This study was designed to prospectively investigate the efficacy and cognitive adverse effects of stereotactic bilateral anterior cingulotomy as a treatment for refractory obsessive-compulsive (OCD) patients for 12 months.

Method: Patients were eligible if they had severe OCD and rigorous treatments had been unsuccessful. Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Clinical Global Impression (CGI) and neuropsychological tests were used to assess the efficacy and cognitive changes of cingulotomy before and 12 months after operation.

Results: The mean improvement rate of the Y-BOCS scores achieved from baseline was 36.0%. Out of 14 patients six met responder criteria; 35% or higher improvement rate on Y-BOCS and CGI improvement of very much or much better at 12-month follow-up. There was no significant cognitive dysfunction after cingulotomy.

Conclusion: Anterior cingulotomy shows few cognitive adverse effects, with about half of the OCD patients demonstrating significant symptomatic improvement.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Cognition Disorders / etiology*
  • Female
  • Gyrus Cinguli / surgery*
  • Humans
  • Male
  • Middle Aged
  • Obsessive-Compulsive Disorder / psychology*
  • Obsessive-Compulsive Disorder / surgery*
  • Psychosurgery / adverse effects
  • Psychosurgery / methods*
  • Severity of Illness Index
  • Treatment Outcome