Brain glucose metabolic changes associated with neuropsychological improvements after 4 months of treatment in patients with obsessive-compulsive disorder

Acta Psychiatr Scand. 2003 Apr;107(4):291-7. doi: 10.1034/j.1600-0447.2003.00070.x.


Objective: The study was designed to elucidate regional brain metabolic changes according to a treatment and their relationship with neuropsychological performance changes in obsessive-compulsive disorder (OCD).

Method: Cerebral glucose metabolic rates were repeatedly measured before and after treatment in 10 patients with OCD using [18F]-2-fluoro-deoxyglucose positron emission tomography (PET). They were compared on a voxel-basis, and the correlations were counted between the regional metabolic changes and the degree to improvement on the neuropsychological assessments.

Results: After treatment, the patients showed significant (P < 0.005, two-tailed) regional metabolic changes in multiple brain areas involving frontal-subcortical circuits and parietal-cerebellar networks. Especially, the metabolic changes of the putamen, the cerebellum, and the hippocampus were significantly correlated with the improvement of the immediate- and delayed-recall scores of the Rey-Osterrieth Complex Figure Test (RCFT).

Conclusion: These results suggest a possibility that metabolic changes of frontal-subcortical and parietal-cerebellar circuit changes may underlie cognitive improvements in patients with OCD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain / metabolism*
  • Cerebellum / physiology
  • Cognition*
  • Female
  • Fluorodeoxyglucose F18
  • Frontal Lobe / physiology
  • Glucose / metabolism*
  • Humans
  • Male
  • Mental Recall
  • Neuropsychological Tests
  • Obsessive-Compulsive Disorder / physiopathology*
  • Obsessive-Compulsive Disorder / therapy*
  • Parietal Lobe / physiology
  • Radiopharmaceuticals
  • Tomography, Emission-Computed
  • Treatment Outcome


  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • Glucose