Field-testing and validation in a primary care setting of a point-of-care test for C-reactive protein

Ann Clin Biochem. 2003 Mar;40(Pt 2):178-80. doi: 10.1258/000456303763046139.


Background: Use of point-of-care testing (POCT) in primary care has increased. There is a need for high-quality field evaluation of POCT before deployment can be considered.

Method: A POCT system for C-reactive protein was evaluated in a routine general practice setting. The standard laboratory method was a dry slide method based in a routine hospital laboratory.

Results: Scatterplots for both venous and capillary blood POCT system results versus the standard laboratory assay produced correlation coefficients of greater than 0.96. Bland-Altman plots indicated that 95% of venous and capillary POCT results fell within +/-10 mg/L of the mean value with no clinically significant difference from laboratory results.

Conclusions: The POCT system performed reliably in a routine general practice setting with satisfactory performance against an accepted laboratory method.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Chemical Analysis
  • C-Reactive Protein / biosynthesis*
  • Calibration
  • Chemistry, Clinical / methods*
  • Humans
  • Point-of-Care Systems
  • Primary Health Care
  • Reproducibility of Results
  • Sensitivity and Specificity


  • C-Reactive Protein