Tuberculosis involving the sphenoid sinus is an unusual entity. Two cases of sphenoid tuberculosis in the pediatric age group are described along with a review of literature. In both cases, MRI was performed for radiological assessment followed by endoscopic biopsy to establish tissue diagnosis. The patients received antitubercular therapy and have shown good clinical response. Tuberculosis as a differential diagnosis of sphenoid lesions is to be kept in mind especially in tropical countries.