Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q complex associates with human CD46

Yasuko Mori; Xuwei Yang; Pilailuk Akkapaiboon; Toshiomi Okuno; Koichi Yamanishi

doi:10.1128/jvi.77.8.4992-4999.2003

Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q complex associates with human CD46

J Virol. 2003 Apr;77(8):4992-9. doi: 10.1128/jvi.77.8.4992-4999.2003.

Authors

Yasuko Mori¹, Xuwei Yang, Pilailuk Akkapaiboon, Toshiomi Okuno, Koichi Yamanishi

Affiliation

¹ Department of Microbiology, Osaka University Medical School, Suita, Osaka 565-0871, USA. ymori@micro.med.osaka-u.ac.jp

Abstract

Human CD46 is a cellular receptor for human herpesvirus 6 (HHV-6). Virus entry into host cells requires a glycoprotein H (gH)-glycoprotein L (gL) complex. We show that the CD46 ectodomain blocked HHV-6 infection and bound a complex of gH-gL and the 80-kDa U100 gene product, designated glycoprotein Q, indicating that the complex is a viral ligand for CD46.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antigens, CD / genetics
Antigens, CD / metabolism*
Baculoviridae / genetics
Cell Fusion
Cell Line
Herpesvirus 6, Human / classification
Herpesvirus 6, Human / genetics
Herpesvirus 6, Human / pathogenicity*
Humans
Ligands
Membrane Cofactor Protein
Membrane Fusion
Membrane Glycoproteins / genetics
Membrane Glycoproteins / metabolism*
Receptors, Virus / metabolism
Recombinant Proteins / metabolism
Viral Envelope Proteins / metabolism*

Substances

Antigens, CD
CD46 protein, human
Ligands
Membrane Cofactor Protein
Membrane Glycoproteins
Receptors, Virus
Recombinant Proteins
Viral Envelope Proteins
glycoprotein H, herpesvirus 6