Abstract
An experimental model of the autoimmune process was developed to study the pathophysiological and structural changes in immunomyopathies. Immune-sera derived from three muscle proteins--myofibril, myosin and actin--produced immunomyopathies for study. The pathophysiological data show that the general muscle efficiency began to decrease with the early stages of treatment and reflected a severe disorder to muscle function with the progression of time. Parallel changes were also observed by light microscopy.
MeSH terms
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Animals
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Autoimmune Diseases / physiopathology*
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Disease Models, Animal
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Fatigue
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Female
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Immune Sera / administration & dosage
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Immunoglobulins* / administration & dosage
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Immunoglobulins* / analysis
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Muscle Proteins / immunology*
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Muscles / drug effects
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Muscles / physiopathology
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Muscular Diseases / immunology
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Muscular Diseases / physiopathology*
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Myasthenia Gravis / immunology
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Rats
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Rats, Inbred Strains
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Respiratory Paralysis / chemically induced
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Succinylcholine / pharmacology
Substances
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Immune Sera
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Immunoglobulins
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Muscle Proteins
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Succinylcholine