[Dynamic variation of serum and stool level of interleukin-2, interleukin-6 and interferon-alpha in children with rotavirus enteritis and its relation to clinical manifestations]

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2002 Sep;16(3):270-3.
[Article in Chinese]


Objective: This study was conducted to observe dynamically the serum and stool level of IL-2, IL-6 and IFN-alpha with RV enteritis, and to analyse the relation of them and their relation to clinical manifestations.

Methods: The double-antibody sandwich ELISA technique was applied.

Results: The positive rate of RV in 119 enteritis cases was 63.0% and the peak month was November. These cytokines had different peak phases in the course of disease. The earliest cytokine which had peak phase was IFN-alpha, the last ones were serum and stool IL-2. There was a negative relation between stool IL-2 and IL-6 (P<0.01). There were positive relation between IL-2 and IFN-alpha, stool IL-6 and IFN-alpha, serum IL-2 and IL-6, stool IL-2 and the recovery time of the enteritis (P<0.01 or P<0.05). Serum and stool level of IL-2 and IFN-alpha had positive relation to the number of lymphocyte plus mononuclear cells (P<0.01 or P<0.05).

Conclusions: IL-2, IL-6 and IFN-alpha play important roles of immunoregulation in RV enteritis, and have close relation to clinical manifestations.

Publication types

  • English Abstract

MeSH terms

  • Enteritis / blood*
  • Enteritis / virology
  • Feces / chemistry
  • Female
  • Humans
  • Infant
  • Interferon-gamma / metabolism*
  • Interleukin-2 / metabolism*
  • Interleukin-6 / metabolism*
  • Male
  • Rotavirus Infections / blood*


  • Interleukin-2
  • Interleukin-6
  • Interferon-gamma