Diminished striatal [123I]iodobenzovesamicol binding in idiopathic cervical dystonia

Ann Neurol. 2003 Apr;53(4):528-32. doi: 10.1002/ana.10527.


Striatal dysfunction is thought to underlie many dystonias. We used [(123)I]iodobenzovesamicol single-photon emission computed tomography imaging to determine the density of cholinergic terminals in the striatum and other brain regions in 13 subjects with idiopathic cervical dystonia. Striatal [(131)I]iodobenzovesamicol binding was reduced. These results support a role for striatal dysfunction in idiopathic dystonias and suggest diminished striatal cholinergic interneuron density in cervical dystonia.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Carrier Proteins / metabolism
  • Cholinergic Fibers / metabolism
  • Corpus Striatum / cytology
  • Corpus Striatum / diagnostic imaging*
  • Female
  • Humans
  • Iodine Radioisotopes
  • Male
  • Membrane Transport Proteins*
  • Middle Aged
  • Piperidines
  • Tetrahydronaphthalenes
  • Tomography, Emission-Computed, Single-Photon*
  • Torticollis / diagnostic imaging*
  • Torticollis / metabolism*
  • Vesicular Acetylcholine Transport Proteins
  • Vesicular Transport Proteins*


  • Carrier Proteins
  • Iodine Radioisotopes
  • Membrane Transport Proteins
  • Piperidines
  • SLC18A3 protein, human
  • Tetrahydronaphthalenes
  • Vesicular Acetylcholine Transport Proteins
  • Vesicular Transport Proteins
  • 5-iodobenzovesamicol