p53 and apoptosis: it's not just in the nucleus anymore

Mol Cell. 2003 Mar;11(3):552-4. doi: 10.1016/s1097-2765(03)00106-0.


The tumor suppressor p53 triggers apoptosis in response to a variety of stress stimuli. Its role as a transcription factor modulating gene expression has been clearly implicated in this process. Two recent publications now argue for an additional direct role of p53 at the mitochondria in inducing apoptosis.

Publication types

  • Comment
  • Review

MeSH terms

  • Alleles
  • Animals
  • Apoptosis*
  • Cell Nucleus / metabolism*
  • Humans
  • Mitochondria / metabolism*
  • Models, Biological
  • Transcriptional Activation
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism
  • Tumor Suppressor Protein p53 / physiology*
  • Up-Regulation


  • Tumor Suppressor Protein p53