Relationship between dendritic cells and the D-fraction-induced Th-1 dominant response in BALB/c tumor-bearing mice

Cancer Lett. 2003 Mar 31;192(2):181-7. doi: 10.1016/s0304-3835(02)00716-4.


Dendritic cells (DCs) are known to not only induce the activation of T cells, but are also associated with the differentiation of T cells. The D-fraction, a beta-glucan extracted from maitake (Grifola frondosa) which expresses anti-tumor effects by establishing a helper (Th)-1 dominance in BALB/c mice, enhanced IL-12p70 production by DCs, when the ratio of CD8alpha(+) DCs to CD8alpha(-) DCs increased. In addition, examination of the tumor rejection effect of D-fraction-stimulated DCs loaded with tumor antigen revealed that tumor growth is inhibited completely by activating CD4(+) T cells and CD8(+) T cells.

MeSH terms

  • Agaricales / chemistry
  • Animals
  • Antigens, Neoplasm / immunology
  • Cell Differentiation / drug effects
  • Cell Division
  • Colonic Neoplasms / immunology*
  • Colonic Neoplasms / pathology
  • Dendritic Cells / cytology
  • Dendritic Cells / drug effects*
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Female
  • Lymphocyte Activation / drug effects
  • Mice
  • Mice, Inbred BALB C
  • Plant Extracts / pharmacology*
  • Th1 Cells / cytology
  • Th1 Cells / drug effects*
  • Th1 Cells / immunology*
  • Time Factors


  • Antigens, Neoplasm
  • Plant Extracts