G-protein beta(3) subunit 825 C/T polymorphism is associated with weight gain during pregnancy

Pharmacogenetics. 2003 Apr;13(4):241-2. doi: 10.1097/00008571-200304000-00009.


A common polymorphism (C825T) of the gene encoding the G-protein beta(3) subunit has been associated with obesity. We examined the hypothesis that this polymorphism affected weight gain during pregnancy. Two hundred and ninety-four women with uncomplicated term deliveries of singleton pregnancies were genotyped. Women homozygous for the T allele (TT) gained significantly more weight than women carrying the C allele (CC and CT groups) (P = 0.006) and had a significantly higher pre-pregnancy body mass index (P = 0.02). The C825T polymorphism of the G-protein beta(3) subunit gene, known to be associated with obesity, is a determinant of weight gain during pregnancy.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Birth Weight
  • Female
  • Heterotrimeric GTP-Binding Proteins / genetics*
  • Humans
  • Infant, Newborn
  • Polymorphism, Single Nucleotide*
  • Pregnancy / genetics
  • Pregnancy / physiology*
  • Weight Gain / genetics*


  • G-protein beta3 subunit
  • Heterotrimeric GTP-Binding Proteins