ER-mediated phagocytosis: a new membrane for new functions

Nat Rev Immunol. 2003 Apr;3(4):280-91. doi: 10.1038/nri1053.

Abstract

Genomics and other high-throughput approaches, such as proteomics, are changing the way we study complex biological systems. In the past few years, these approaches have contributed markedly to improving our understanding of phagocytosis. Indeed, the ability to study biological systems by monitoring hundreds of proteins provides a level of resolution that is not attainable by the usual 'one protein at a time' approach. In this article, I discuss how proteomic approaches have revealed surprising findings that enable us to revisit established concepts, such as the origin of the phagosome membrane, and to propose new models of cell organization and the link between innate and adaptive immunity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation
  • Cell Membrane / immunology
  • Cell Membrane / ultrastructure
  • Endoplasmic Reticulum / immunology*
  • Endoplasmic Reticulum / ultrastructure
  • Humans
  • Membrane Microdomains / immunology
  • Membrane Microdomains / ultrastructure
  • Membrane Proteins / immunology
  • Models, Immunological
  • Phagocytosis / immunology*
  • Phagosomes / immunology
  • Phagosomes / ultrastructure
  • Proteomics

Substances

  • Membrane Proteins