Yeasts make their mark

Nat Cell Biol. 2003 Apr;5(4):294-9. doi: 10.1038/ncb0403-294.


Budding and fission yeast serve as genetic model organisms for the study of the molecular mechanisms of cell polarity in single cells. Similar to other polarized eukaryotic cells, yeast cells have polarity programmes that regulate where they grow and divide. Here, we describe recent advances in defining the proteins that establish cell polarity and the numerous molecular interactions that may link these factors to the actin cytoskeleton. As many of these components are identified, a comprehensive understanding of complex pathways is beginning to emerge.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Division / physiology*
  • Cell Polarity / physiology*
  • Cytoskeleton / genetics
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / metabolism*
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism*
  • Humans
  • Models, Biological
  • Signal Transduction / genetics
  • Yeasts / cytology
  • Yeasts / genetics
  • Yeasts / metabolism*


  • Fungal Proteins