Anti-interferon-gamma antibodies in the treatment of autoimmune diseases

Curr Opin Mol Ther. 2003 Feb;5(1):52-7.


Interferon (IFN)-gamma is an important immune regulator in normal immunity. When IFN gamma production is disturbed, various autoimmune diseases (ADs) can develop, in which we suggest that anti-IFN gamma could have a beneficial effect. Depending on the cell type in which IFN gamma synthesis is disturbed, different clinical manifestations may result. We have also proposed to remove tumor necrosis factor (TNF)-alpha, together with certain types of IFNs, to treat various ADs and AIDS, also an autoimmune condition. Anti-IFN gamma has been tested in several T-helper cell (Th1) ADs, including rheumatoid arthritis (RA), multiple sclerosis (MS), corneal transplant rejection, uveitis, Type I diabetes, schizophrenia (anti-IFN gamma and anti-TNF alpha), and various autoimmune skin diseases (alopecia areata, psoriasis vulgaris, vitiligo, pemphigus vulgaris and epidermolysis bullosa). A strong, sometimes striking, therapeutic response followed administration of anti-IFN gamma, indicating that it may be a promising therapy for Th1 ADs.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Animals
  • Antibodies / therapeutic use*
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / therapy*
  • Humans
  • Interferon-gamma / immunology*
  • Treatment Outcome


  • Antibodies
  • Interferon-gamma