Effect of Eurycoma longifolia Jack on libido in middle-aged male rats

J Basic Clin Physiol Pharmacol. 2002;13(3):249-54. doi: 10.1515/jbcpp.2002.13.3.249.

Abstract

The effect of increasing doses of various fractions of Eurycoma longifolia Jack extracts on libido was examined in middle-aged male rats. The results showed that a high dose (800 mg/kg) of all E. longifolia Jack extracts significantly increased mount frequency (MF) (P < 0.05) over that of untreated controls, but had no effect on the frequency of intromission or ejaculation. Methanol, chloroform, water, and butanol fractions exhibited MF of 2.5 +/- 0.1, 2.6 +/- 0.3, 2.5 +/- 0.1 and 2.6 +/- 0.2, respectively, in adult, middle-aged male rats, and retired breeders versus 2.3 +/- 0.1 in untreated controls. This translated to a minor increase in MF of 8.7%, 13.0%, 8.7%, and 13.0% for these fractions, respectively, during the 20-minute observation period. The results of this study show that E. longifolia Jack extracts can increase libido in middle-aged male rats.

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Ejaculation / drug effects
  • Eurycoma / chemistry*
  • Libido / drug effects*
  • Male
  • Plant Extracts / pharmacology
  • Plant Roots / chemistry
  • Rats
  • Rats, Sprague-Dawley
  • Solvents
  • Stimulation, Chemical

Substances

  • Plant Extracts
  • Solvents