Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2003 Apr;4(4):276-84.
doi: 10.1038/nrm1075.

Histone Acetylation and Deacetylation in Yeast

Affiliations
Review

Histone Acetylation and Deacetylation in Yeast

Siavash K Kurdistani et al. Nat Rev Mol Cell Biol. .

Abstract

Histone acetylation and deacetylation in the yeast Saccharomyces cerevisiae occur by targeting acetyltransferase and deacetylase enzymes to gene promoters and, in an untargeted and global manner, by affecting most nucleosomes. Recently, new roles for histone acetylation have been uncovered, not only in transcription but also in DNA replication, repair and heterochromatin formation. Interestingly, specific acetylatable lysines can function as binding sites for regulatory factors. Moreover, histone deacetylation is not only repressive but can be required for gene activity.

Similar articles

See all similar articles

Cited by 217 articles

See all "Cited by" articles

Publication types

MeSH terms

Substances

LinkOut - more resources

Feedback