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. 2003 Apr;4(4):276-84.
doi: 10.1038/nrm1075.

Histone Acetylation and Deacetylation in Yeast


Histone Acetylation and Deacetylation in Yeast

Siavash K Kurdistani et al. Nat Rev Mol Cell Biol. .


Histone acetylation and deacetylation in the yeast Saccharomyces cerevisiae occur by targeting acetyltransferase and deacetylase enzymes to gene promoters and, in an untargeted and global manner, by affecting most nucleosomes. Recently, new roles for histone acetylation have been uncovered, not only in transcription but also in DNA replication, repair and heterochromatin formation. Interestingly, specific acetylatable lysines can function as binding sites for regulatory factors. Moreover, histone deacetylation is not only repressive but can be required for gene activity.

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