The power and the promise of DNA methylation markers

Nat Rev Cancer. 2003 Apr;3(4):253-66. doi: 10.1038/nrc1045.


The past few years have seen an explosion of interest in the epigenetics of cancer. This has been a consequence of both the exciting coalescence of the chromatin and DNA methylation fields, and the realization that DNA methylation changes are involved in human malignancies. The ubiquity of DNA methylation changes has opened the way to a host of innovative diagnostic and therapeutic strategies. Recent advances attest to the great promise of DNA methylation markers as powerful future tools in the clinic.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Biomarkers, Tumor / analysis*
  • DNA Methylation*
  • DNA, Neoplasm / analysis*
  • Genetic Markers
  • Humans
  • Neoplasms / blood
  • Neoplasms / genetics*
  • Sensitivity and Specificity


  • Biomarkers, Tumor
  • DNA, Neoplasm
  • Genetic Markers