Role of hormonal risk factors in HER2-positive breast carcinomas

Br J Cancer. 2003 Apr 7;88(7):1032-4. doi: 10.1038/sj.bjc.6600844.


Examination of parity, age at menarche and at menopause by HER2 status in a large series of breast carcinomas showed a statistically significant increased-frequency of HER2-positive tumours in lower risk subgroups. The findings suggest a difference in the protective role of hormone-related risk factors between HER2-positive and -negative tumours.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms / etiology*
  • Female
  • Humans
  • Menarche*
  • Menopause*
  • Middle Aged
  • Parity
  • Receptor, ErbB-2 / analysis*
  • Risk Factors


  • Receptor, ErbB-2