Regulation of Chromosome Condensation and Segregation

Curr Opin Genet Dev. 2003 Apr;13(2):185-90. doi: 10.1016/s0959-437x(03)00027-3.


Regulated and controlled chromosome condensation and segregation is essential for the transmission of genetic information from one generation to the next. A myriad of techniques has been utilized over the last few decades to identify proteins required for the organized compaction of the massive length of a cell's DNA. A full understanding of the components and processes involved relies on further work, exploiting biochemical, genetic, cytological, and proteomics approaches to complete the picture of how a cell packages and partitions its genome during the cell cycle.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chromosome Segregation / physiology*
  • Chromosomes / metabolism*
  • Humans