Hypertension, anti-hypertensive drug therapy and erectile dysfunction in diabetes

Diabet Med. 2003 Apr;20(4):290-3. doi: 10.1046/j.1464-5491.2003.00911.x.


Aims: Erectile dysfunction (ED) is common in diabetes and may be related to the high prevalence of hypertension and consequent anti-hypertensive drug therapy in diabetic patients. The risk factors for ED were studied with particular reference to hypertension and anti-hypertensive drugs.

Methods: We performed a retrospective case note analysis of 763 consecutive male patients (34% Type 1 diabetes, 65% Type 2 diabetes) attending an adult diabetic clinic to collect data on risk factors for ED. We specifically recorded the use of anti-hypertensive drugs.

Results: Two hundred and ninety-nine (39%) patients had ED. Mean age of patients with ED (61 years) was higher than those without (mean age 51 years, P < 0.001). The mean age of hypertensive patients was also significantly higher than those without. On multivariate regression analysis, age (P < 0.001), macrovascular disease (P < 0.001), sensorimotor neuropathy (P < 0.001) and HbA1c (P < 0.05) predicted ED. Neither hypertension nor any anti-hypertensive medication independently predicted ED.

Conclusion: Our data suggest that ED in diabetic patients with hypertension may be related to the higher age and prevalence of macrovascular disease rather than hypertension or its treatment.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Angiotensin-Converting Enzyme Inhibitors / adverse effects
  • Antihypertensive Agents / adverse effects*
  • Antihypertensive Agents / therapeutic use
  • Benzothiadiazines
  • Calcium Channel Blockers / adverse effects
  • Diabetes Complications*
  • Diabetes Mellitus / drug therapy
  • Diuretics
  • Erectile Dysfunction / etiology*
  • Humans
  • Hypertension / complications*
  • Male
  • Middle Aged
  • Risk Factors
  • Sodium Chloride Symporter Inhibitors / adverse effects


  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive Agents
  • Benzothiadiazines
  • Calcium Channel Blockers
  • Diuretics
  • Sodium Chloride Symporter Inhibitors