Notch signaling: endocytosis makes delta signal better

Curr Biol. 2003 Apr 1;13(7):R273-5. doi: 10.1016/s0960-9822(03)00199-4.

Abstract

Endocytosis of cell surface receptors is involved in down-regulation of receptor activity. Recent findings indicate that, paradoxically, endocytosis of a membrane-spanning ligand may up-regulate receptor activity: the zebrafish E3 ligase Mind bomb promotes the endocytosis of Delta and is required for efficient activation of Notch.

Publication types

  • Review

MeSH terms

  • Animals
  • Endocytosis / genetics
  • Endocytosis / physiology*
  • Gene Expression Regulation / genetics
  • Gene Expression Regulation / physiology*
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins / genetics*
  • Membrane Proteins / metabolism*
  • Receptors, Cell Surface / metabolism*
  • Receptors, Notch
  • Signal Transduction
  • Ubiquitin-Protein Ligases / metabolism
  • Xenopus
  • Zebrafish
  • Zebrafish Proteins / metabolism

Substances

  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Receptors, Cell Surface
  • Receptors, Notch
  • Zebrafish Proteins
  • delta protein
  • Ubiquitin-Protein Ligases
  • mib1 protein, zebrafish