Wiring the angiogenic switch: Ras, Myc, and Thrombospondin-1

Cancer Cell. 2003 Mar;3(3):199-200. doi: 10.1016/s1535-6108(03)00056-4.


The formation of a blood supply is critical for tumor growth and metastasis; however, understanding the relationship of cellular transformation to tumor angiogenesis has been limited by the multifactorial nature of both processes. In this issue of Cancer Cell, Watnick and colleagues use a genetically defined tumor model system to determine the link between ras, myc, and angiogenesis and identify Thrombospondin-1 as being the critical regulator of angiogenesis in this system (Watnick et al., 2003).

Publication types

  • Comment

MeSH terms

  • Gene Expression Regulation, Neoplastic
  • Humans
  • Models, Biological
  • Neovascularization, Pathologic / genetics
  • Neovascularization, Pathologic / metabolism
  • Neovascularization, Pathologic / physiopathology*
  • Proto-Oncogene Proteins c-myc / metabolism*
  • Thrombospondin 1 / genetics
  • Thrombospondin 1 / metabolism*
  • ras Proteins / metabolism*


  • Proto-Oncogene Proteins c-myc
  • Thrombospondin 1
  • ras Proteins