Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way

Cancer Cell. 2003 Mar;3(3):201-2. doi: 10.1016/s1535-6108(03)00049-7.

Abstract

Although the genesis of invasive squamous cell carcinoma (SCC) from stratified epithelia of the skin is considered to be a complex, multistage process, recent work on human epidermis reveals that sustained Ras signaling coupled with suppression of Ras-induced growth arrest is sufficient to drive the entire process and that the alpha6beta4 integrin and its laminin 5 ligand are essential components of this process.

Publication types

  • Review

MeSH terms

  • Animals
  • Carcinoma / genetics*
  • Carcinoma / pathology
  • Genes, ras*
  • Humans
  • I-kappa B Kinase
  • Integrin alpha6beta4 / metabolism*
  • Laminin / metabolism
  • Ligands
  • Models, Biological
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / genetics
  • NF-kappa B / metabolism
  • Neoplasm Invasiveness
  • Neoplasms, Squamous Cell / genetics*
  • Neoplasms, Squamous Cell / pathology
  • Protein-Serine-Threonine Kinases / metabolism
  • Signal Transduction
  • Skin Neoplasms / genetics*
  • Skin Neoplasms / pathology
  • ras Proteins / metabolism

Substances

  • Integrin alpha6beta4
  • Laminin
  • Ligands
  • NF-kappa B
  • Protein-Serine-Threonine Kinases
  • CHUK protein, human
  • I-kappa B Kinase
  • IKBKB protein, human
  • IKBKE protein, human
  • ras Proteins